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According to the results obtained in this study Chrysanthellum americanum extract could protect animals against oxidative and nitrosative stresses eventually by preventing lipid peroxidation and regulating the balance between free radicals and antioxidant defense system

These phenomena further cause the apoptosome activation and caspase-mediated apoptosis ( 2+ overload, mitochondrial membrane permeability transition pore (mPTP) opening, mitochondrial-dependent apoptosis, and even cell death (Wu et al., 2020a)

Nat Neurosci 11:420422 Miyazaki K, Masamoto K, Morimoto N et al (2011) Early and progressive impairment of spinal blood flow-glucose metabolism coupling in motor neuron degeneration of ALS model mice

Intake estimation of total and individual flavan-3-ols, proanthocyanidins and theaflavins, their food sources and determinants in the European Prospective Investigation into Cancer and Nutrition (EPIC) study